Cincinnati at Chi. Cubs 2:20 PM ET
Cody Bellinger is preparing for what could be his final series with the Chicago Cubs.
Chi. White Sox at Detroit 6:40 PM ET
What once seemed impossible now appears inevitable.
Philadelphia at Washington 6:45 PM ET
The Philadelphia Phillies have already clinched the National League East title and a first-round bye into the NL Division Series. However, Rob Thompson's squad still have plenty to play for heading into their regular-season-ending three-game road series against the Washington Nationals beginning on Friday night.
Pittsburgh at NY Yankees 7:05 PM ET
After clinching the American League East title, the only remaining items for the New York Yankees to check off are attempting to secure the best record in the AL and seeing how many more homers Aaron Judge can hit.
Miami at Toronto 7:07 PM ET
Vladimir Guerrero Jr. needs three hits against the visiting Miami Marlins in a three-game series that begins Friday night to become the sixth Toronto Blue Jay with a 200-hit season.
Houston at Cleveland 7:10 PM ET
The Cleveland Guardians and the Houston Astros could meet in this year's postseason, but for now, the two division winners aim to finish the regular season strong when they begin a three-game series on Friday in Cleveland.
Tampa Bay at Boston 7:10 PM ET
With postseason berths out of reach for both teams, the Boston Red Sox host the Tampa Bay Rays to begin a season-ending, three-game series on Friday.
Kansas City at Atlanta 7:20 PM ET
The final weekend of the season marks a sprint toward the playoffs for both the Atlanta Braves and Kansas City Royals.
Baltimore at Minnesota 8:10 PM ET
The Minnesota Twins need a lot of help to stay alive in their bid for the postseason.
NY Mets at Milwaukee 8:10 PM ET
After a pair of weather-related postponements, the New York Mets will resume their quest for a postseason berth against the host Milwaukee Brewers on Friday in the opener of the three-game series that could determine the National League wild-card race.
LA Dodgers at Colorado 8:10 PM ET
The Los Angeles Dodgers are accustomed to playing in the postseason, but Shohei Ohtani is going to get a taste of it for the first time in his seven-year career.
Texas at LA Angels 9:38 PM ET
The six starts Jacob deGrom made last season were enough to help the Texas Rangers win the World Series for the first time ever.
San Diego at Arizona 9:40 PM ET
There are many unknowns as the Arizona Diamondbacks finish the regular season with a three-game series against the San Diego Padres.
Oakland at Seattle 10:10 PM ET
The Athletics have bid adieu to Oakland, but they still have some work to do.
St. Louis at San Francisco 10:15 PM ET
The San Francisco Giants will find themselves staring at a potential difference-maker in their future when Paul Goldschmidt and the St. Louis Cardinals visit Friday night for the start of the final three games of the regular season.