Toronto at NY Yankees 1:05 PM ET
Although Vladimir Guerrero Jr. has produced big games against the New York Yankees in his career, he has never done so as a member of a division-leading team in September.
Washington at Chi. Cubs 2:20 PM ET
The Chicago Cubs will try to continue taking advantage of a soft part of their schedule when they host the Washington Nationals on Saturday afternoon.
Philadelphia at Miami 4:10 PM ET
The Miami Marlins certainly are enjoying Sandy Alcantara's resurgence, and the former National League Cy Young Award winner hopes to deliver another strong outing Saturday afternoon when his team hosts the Philadelphia Phillies.
Chi. White Sox at Detroit 6:10 PM ET
Tarik Skubal made franchise history in his most recent start.
NY Mets at Cincinnati 6:40 PM ET
Edwin Diaz probably won't be available to save a potential win for Jonah Tong on Saturday night.
Milwaukee at Pittsburgh 6:40 PM ET
As the Milwaukee Brewers chase home-field advantage throughout the postseason, they are dealing with a bullpen ravaged by injuries as well as the absence of other key lineup contributors.
LA Dodgers at Baltimore 7:05 PM ET
The Los Angeles Dodgers have hit a rough patch at an inopportune time. They've lost four games in a row going into Saturday night's matchup with the host Baltimore Orioles.
Cleveland at Tampa Bay 7:05 PM ET
The race for the third and final wild-card spot in the American League is narrowing, with both the Cleveland Guardians and Tampa Bay Rays moving back into contention.
Seattle at Atlanta 7:15 PM ET
If the Seattle Mariners miss the playoffs, their season-long road woes might be the primary culprit.
San Francisco at St. Louis 7:15 PM ET
While the streaking San Francisco Giants climbed back into the playoff race, pitcher Justin Verlander added to his Hall of Fame credentials.
Houston at Texas 7:15 PM ET
The Texas Rangers will look to move a step closer to a spot in the wild-card race when they face the rival Houston Astros on Saturday night in the second game of a three-game American League West series in Arlington, Texas.
Minnesota at Kansas City 7:15 PM ET
The Kansas City Royals are making a push to reach the final wild-card position in the American League, but they might not have star Bobby Witt Jr. to help the cause for the immediate future.
San Diego at Colorado 8:10 PM ET
San Diego's Randy Vasquez celebrated the birth of his daughter this past week, and his first chance to pitch again will come in a pennant race in Denver on Saturday night.
Boston at Arizona 8:10 PM ET
resurgent right-hander Lucas Giolito -- when they face the Arizona Diamondbacks on Saturday in Phoenix.
Athletics at LA Angels 9:38 PM ET
Two starting pitchers looking to snap long winless streaks take the mound Saturday night when the Athletics face the Los Angeles Angels in Anaheim, Calif.