Toronto at Baltimore 12:35 PM ET
The Toronto Blue Jays have suddenly fallen into a rut.
Arizona at Detroit 1:10 PM ET
Chris Paddack suddenly finds himself with the American League Central leaders, and the Detroit Tigers have high hopes for him.
Boston at Minnesota 1:10 PM ET
This is the time of the season when a hug can set off alarm bells.
Washington at Houston 2:10 PM ET
With All-Star shortstop Jeremy Pena starting a rehab assignment with Triple-A Sugar Land and outfielders Yordan Alvarez and Jake Meyers continuing to ramp up baseball activities, the Astros are inching closer to having several starters back from the injured list.
Atlanta at Kansas City 2:10 PM ET
A disappointing season continues to get bleaker for the Atlanta Braves.
Philadelphia at Chi. White Sox 2:10 PM ET
Eyeing their second straight road series victory, the Philadelphia Phillies will turn to a pitcher who senses he likely is a lame duck in the rotation.
Chi. Cubs at Milwaukee 2:10 PM ET
Left-hander Shota Imanaga will try to help the visiting Chicago Cubs avoid a sweep of their three-game series against division rival Milwaukee on Wednesday afternoon.
Pittsburgh at San Francisco 3:45 PM ET
Pittsburgh's Bryan Reynolds will attempt to complete a homecoming hat trick Wednesday afternoon when the visiting Pirates go for a sweep of the San Francisco Giants.
NY Mets at San Diego 4:10 PM ET
After flying into San Diego with a seven-game winning streak, the New York Mets hope to fly home Wednesday with a win that would avoid a series sweep by the Padres.
Colorado at Cleveland 6:40 PM ET
Kyle Manzardo of the Cleveland Guardians is a man of few words, so he lets his bat speak for him.
Tampa Bay at NY Yankees 7:05 PM ET
In a run of inconsistent play, Cody Bellinger is among the most consistent hitters for the New York Yankees.
LA Dodgers at Cincinnati 7:10 PM ET
One day after a rare bad night at the plate, Shohei Ohtani will try his luck on the mound and attempt to help the visiting Los Angeles Dodgers complete a three-game sweep of the Cincinnati Reds on Wednesday night.
Miami at St. Louis 7:45 PM ET
The Miami Marlins have had to adjust their roster on the fly during their final series ahead of Thursday's trade deadline.
Texas at LA Angels 9:38 PM ET
Heading into a 13-game homestand, it appeared the Los Angeles Angels would be sellers at Thursday's trade deadline, with veteran closer Kenley Jansen drawing significant interest.
Seattle at Athletics 10:05 PM ET
The Athletics are far out of the postseason race, but the young club has won five of its past six games entering Wednesday night's series finale against the Seattle Mariners at West Sacramento, Calif.