Baltimore at Cleveland 1:10 PM ET
A make-or-break homestand for the Guardians has been the former, allowing Cleveland to claw its way back into the American League wild-card hunt.
Toronto at Detroit 6:40 PM ET
The Toronto Blue Jays and Detroit Tigers each have 60 victories, but the two division leaders have been heading in opposite directions.
San Diego at St. Louis 7:45 PM ET
The San Diego Padres will be looking to generate more offense and play better defense as they continue their push toward the postseason.
Athletics at Houston 8:10 PM ET
Even with four regulars on the injured list, Houston Astros manager Joe Espada stuck with his scheduled off days for Jose Altuve and Cam Smith on Wednesday in the finale of a three-game series against the Arizona Diamondbacks in Phoenix.
Seattle at LA Angels 9:38 PM ET
The Los Angeles Angels, after getting swept in a three-game series by the New York Mets to put a dent in their postseason hopes, begin a make-or-break 13-game homestand against the Seattle Mariners on Thursday in Anaheim, Calif.