Boston at Seattle 4:10 PM ET
Thanks to batterymates Cal Raleigh and Bryan Woo, the Seattle Mariners will have a chance to win their three-game series against the visiting Boston Red Sox.
Philadelphia at Miami 6:40 PM ET
Philadelphia right fielder Nick Castellanos figures to be back in the lineup when the visiting Phillies continue their four-game series against the Miami Marlins on Wednesday.
Colorado at Washington 6:45 PM ET
The visiting Colorado Rockies will vie for their first four-game winning streak of the season on Wednesday night when they play the third contest of their four-game series against the spiraling Washington Nationals.
LA Angels at NY Yankees 7:05 PM ET
For the first time in nearly a decade, the New York Yankees are scoreless in three straight games.
Arizona at Toronto 7:07 PM ET
The Toronto Blue Jays enter the middle game of their three-game series against the visiting Arizona Diamondbacks on Wednesday night with a big question in the outfield.
Minnesota at Cincinnati 7:10 PM ET
The Cincinnati Reds haven't had a lot of luck this season with late rallies, save for their last two games.
NY Mets at Atlanta 7:15 PM ET
The New York Mets will send struggling Paul Blackburn to the mound on Wednesday night as they attempt to end their season-long four-game losing streak when they visit the Atlanta Braves.
Baltimore at Tampa Bay 7:35 PM ET
The Baltimore Orioles are hoping for another strong major league performance from Trevor Rogers when he starts Wednesday night against the host Tampa Bay Rays in the third contest of a four-game series.
Kansas City at Texas 8:05 PM ET
Kansas City's offense has revved up thanks to an emphasis on aggressive swings early in at-bats.
Cleveland at San Francisco 9:45 PM ET
One day after seeing Rafael Devers don their home team's uniform for the first time, San Francisco Giants fans will get an opportunity to get reacquainted with another star, Justin Verlander, when he returns from the injured list to face the Cleveland Guardians on Wednesday night.
Houston at Athletics 10:05 PM ET
Framber Valdez is one of the hottest pitchers in the majors, and the left-hander will look to post his seventh consecutive victory when the Houston Astros face the Athletics on Wednesday night at West Sacramento, Calif.
San Diego at LA Dodgers 10:10 PM ET
For the fourth time this season, the Los Angeles Dodgers will welcome a pitcher back from Tommy John surgery when right-hander Emmet Sheehan faces the visiting San Diego Padres on Wednesday night.